Thermo Fisher Scientific STAT6 Polyclonal Antibody
STAT6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. Human STAT6에 반응하며, 고순도 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human STAT6. Recombinant protein control fragment (Product #RP-94781). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789138 |
Product Specific Information
Immunogen sequence:
VYPPHSHSIP PYQGLSPEES VNVLSAFQEP HLQMPPSLGQ MSLPFDQPHP QGLLPCQPQE HAVSSPDPLL CSDVTMVEDS CLSQPVTAFP QGTWIGEDIF PPLLPPTEQD LTKLLLEGQG ESGGGSLGAQ PLLQPSHYGQ SGISMSHMDL R
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. STAT6-deficient (Stat6-/-) cells show impaired IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4-mediated proliferation.
STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. STAT6 is critically involved in Th2 immune response and is crucial for IL-4-mediated biological responses. It naturally exists in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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