Thermo Fisher Scientific HSPBAP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Jurkat, Raji
• Predicted reactivity: Chimpanzee (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HSPBAP1 (HSPB (heat shock 27kDa) associated protein 1), also known as PASS1 (protein associated with small stress protein 1), is a 488 amino acid cytoplasmic protein that contains one JMJC (Jumonji C) domain and shares 80% identity with its rat homolog, PASS1.
Widely expressed with highest expression in ovary, thymus, and pancreas, HSPBAP1 is thought to play a role in mediating cellular stress responses within the cell.
Due to the presence of a JMJC domain, HSPBAP1 may be involved in chromatin remodeling events.
Defects or translocations in the gene encoding HSPBAP1 are associated with renal cell carcinoma 1 (RCC1), suggesting a possible role for HSPBAP1 in carcinogenesis.
Three isoforms of HSPBAP1 exist due to alternative splicing events.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.