Thermo Fisher Scientific ALK Monoclonal Antibody (OTI2D5), TrueMAB
인간 ALK 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western Blot에 최적화되어 있습니다. TrueMAB 형식으로 제작되었으며, 고순도 친화 크로마토그래피 정제 및 안정적 PBS/BSA/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often create a fusion gene between ALK (chromosome 2) and NPM (chromosome 5), resulting in an oncogenic NPM-ALK fusion protein.
ALK encodes a novel receptor tyrosine kinase with transmembrane and extracellular domains, which are absent in the NPM-ALK fusion product. It shows high sequence similarity to LTK and plays an important role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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