Thermo Fisher Scientific STAR Polyclonal Antibody
인간 STAR 단백질에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상형 항체로, 장기 보관 시 -20°C에서 안정적. 스테로이드 생성 관련 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human STAR. Recombinant protein control fragment (Product #RP-93803) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647994 |
Product Specific Information
- Immunogen sequence:
QDNGDKVMSK VVPDVGKVFR LEVVVDQPME RLYEELVERM EAMGEWNPNV KEIKVLQKIG KDTFITHELA - Antigen sequence identity:
Mouse - 89%, Rat - 86%
Target Information
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are associated with autosomal Lipoid Congenital Adrenal Hyperplasia (LCAH), resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR remains to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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