Thermo Fisher Scientific NR0B2 Polyclonal Antibody
NR0B2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 사람과 생쥐 시료에 반응하며, 친화 크로마토그래피로 정제됨. PBS/glycerol 완충액에 보관되며 -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NR0B2 (Accession Q15466), corresponding to amino acid residues L118–C168. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851896 |
Product Specific Information
This antibody detects endogenous levels of total NR0B2.
Target Information
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. It belongs to the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones. Some members of this family, including NR0B2, are considered orphan nuclear receptors as their ligands are unknown.
The protein interacts with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation, and also with estrogen receptors, leading to inhibition of function. Studies suggest that NR0B2 represses nuclear hormone receptor-mediated transactivation through competition with coactivators and direct transcriptional repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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