Thermo Fisher Scientific POLH Polyclonal Antibody
POLH 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 분석에 적합. Human, Mouse, Rat 시료 반응성. 합성 펩타이드 면역원 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human POLH (Accession Q9Y253), corresponding to amino acid residues Q541–T591 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851894 |
Product Specific Information
Antibody detects endogenous levels of total POLH.
Target Information
The XPA gene encodes a zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair.
The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription.
The XPG gene product is an endonuclease that cuts on the 3′ side of a DNA lesion during nucleotide excision repair.
Molecular defects in the XP variant (POLH) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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