Thermo Fisher Scientific KLRB1 Monoclonal Antibody (OTI1D8), TrueMAB
인간 KLRB1(CD161)을 인식하는 Mouse IgG1 단클론 항체. Western blot과 IHC(Paraffin)에서 1:500 희석으로 검증됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. NK 세포 및 T 세포 연구용으로 적합.
- 카탈로그번호
- TA809736
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 67–225 of human KLRB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD161) protein is a type II membrane protein with an external C terminus. It is expressed by almost all NK cells and a subset of CD3⁺ T cells. The KLRB1 antigen forms a homodimeric cell surface protein (40–44 kDa) and plays an inhibitory role on NK cells.
Activation of KLRB1 stimulates acid sphingomyelinase/SMPD1 and increases intracellular ceramide levels, along with activation of AKT1/PKB and RPS6KA1/RSK1 kinases, promoting T cell proliferation by anti-CD3 stimulation. KLRB1 acts as a lectin binding to Gal-α(1,3)Gal and N-acetyllactosamine epitopes, and interacts with CLEC2D/LLT1 ligand to inhibit NK cell-mediated cytotoxicity and interferon-gamma secretion.
KLRB1 contains an extracellular domain with C-type lectin motifs, a transmembrane domain, and a cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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