Thermo Fisher Scientific Human CDK1/Cyclin B, His Tag Recombinant Protein
인간 CDK1/Cyclin B 재조합 단백질로 키나아제 활성 분석에 적합합니다. Insect cell에서 발현된 His-tag 단백질이며, 고순도(80%)로 정제되어 있습니다. 세포주기 연구 및 CDK 관련 신호전달 연구에 활용 가능합니다.
- 카테고리
- Protein
- 판매단위
- pk
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Thermo Fisher Scientific Human CDK1/Cyclin B, His Tag Recombinant Protein
Applications
- Kinase Assay (KA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | Full length |
| Tag | His-tag |
| Molecular Weight | 91 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | 80% by SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 20 mM Tris (pH 7.5), 0.5 mM EDTA, 2 mM DTT, 150 mM NaCl, 0.01% Triton X-100, 20% glycerol |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use in original packaging until exhausted.
- For larger sizes, aliquoting can reduce freeze/thaw cycles (do not prepare aliquots below 20 µL).
- Never store kinase diluted.
- Properly stored at -80°C, the product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Full Length
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis.
CDK1 acts as the catalytic subunit of the M-Phase Promoting Factor, a protein kinase complex that induces entry into mitosis and is conserved among eukaryotes.
Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal, delaying apoptosis onset.
Therapeutic potential of CDK inhibitor NU2058 has been demonstrated in androgen-independent prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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