Thermo Fisher Scientific TERT Polyclonal Antibody
TERT 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot, ICC/IF, Flow cytometry에 사용 가능. 인간 시료 반응성, 비결합형 액상 형태, 안정적 저장 (-20°C). 연구용으로만 사용.
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- PA5142844
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-QLRELSEAEVRQHRE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933487 |
Product Specific Information
- Expected to recognize both reported isoforms (NP_937983.2; NP_001180305.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.
The enzyme consists of a protein component with reverse transcriptase activity, encoded by the TERT gene, and an RNA component which serves as a template for the telomere repeat.
Telomerase expression plays a role in cellular senescence and is normally repressed in postnatal somatic cells, resulting in progressive telomere shortening.
Deregulation of telomerase expression may contribute to oncogenesis.
Studies in mouse suggest telomerase participates in chromosomal repair through de novo synthesis of telomere repeats at double-stranded breaks.
Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; some full-length sequences remain undetermined.
Alternative splicing at this locus is thought to regulate telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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