Thermo Fisher Scientific Human CENPW Synthetic Peptide
인간 CENPW 아미노 말단의 16개 아미노산으로 구성된 합성 펩타이드. 항체 PA5-34441의 블로킹 펩타이드로 사용 가능. 암 관련 CENPW 단백질 연구 및 키네토코어 기능 분석에 적합. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human CENPW.
PEP-1483 can be used as a blocking peptide with polyclonal antibody PA5-34441.
Target Information
CENPW was initially identified as a gene upregulated in multiple cancers. Its overexpression in mouse fibroblast cells led to distinct cancer-specific phenotypes.
CENPW is a nuclear protein associated with CENPT, a component of the CENPA nucleosome complex in the centromere, and is required for proper kinetochore function.
It interacts with the nucleolar phosphoprotein nucleophosmin (B23), which may assist kinetochore assembly during interphase.
Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line and zebrafish embryo induced apoptosis, suggesting that elevated CENPW levels trigger apoptotic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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