Thermo Fisher Scientific FGF Receptor 1 Monoclonal Antibody (M17D10)
FGFR1 단백질을 인식하는 마우스 모노클로날 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 단백질 A로 정제된 액상 형태로 제공되며 보존제가 포함되지 않음. 인간 FGFR1에 특이적으로 반응하며 연구용으로 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M17D10 |
| Immunogen | Recombinant human ectodomain of FGFr1 beta expressed in E. coli from pro23 to his415 (23–415); antigen contained NH₂-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor (FGFR) family, which includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity binding sites for 17 fibroblast growth factors (FGF1–17). The FGFR family is crucial in various biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms that are differentially expressed during embryonic development and in adult tissues. Mutations or aberrations in FGFR1 are associated with several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal rearrangements involving FGFR1 are linked to stem cell myeloproliferative disorders and stem cell leukemia/lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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