Thermo Fisher Scientific FGF Receptor-alpha Monoclonal Antibody (M2F12)
FGF Receptor-alpha 단클론 항체(M2F12)는 인간, 마우스, 랫트에 반응하며 Western blot, IHC(F), IP에 사용 가능합니다. 단백질 A로 정제된 액상 항체로, 보존제 없이 PBS(pH 7.4)에 용해되어 있습니다. FGFR1 관련 신호전달 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M2F12 |
| Immunogen | Recombinant human ectodomain of FGFr1 alpha expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) belongs to the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 fibroblast growth factors (FGF1–17).
These receptors are crucial in mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic and adult stages.
Mutations or aberrations in FGFR1 are linked to disorders such as Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, and other skeletal abnormalities.
Chromosomal rearrangements involving FGFR1 are associated with stem cell myeloproliferative disorders and leukemia/lymphoma syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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