Thermo Fisher Scientific DUSP11 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DUSP11, validated for ICC/IF at 0.25–2 µg/mL. Recombinant human DUSP11 used as immunogen. Unconjugated, liquid form, purified by antigen affinity chromatography. Suitable for research use in MAPK pathway studies.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human DUSP11 (Recombinant protein control fragment, Product #RP-105747) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662204 |
Product Specific Information
Immunogen sequence:
MSQWHHPRSGW GRRRDFSGRS SAKKKGGNHI PERWKDYLPV GQRMPGTRFI AFKVPLQKSF EKKLAPEECF SPLDLFNKIR EQNEELGLII DLTYTQRYYK PEDLPETVPY LKIFTVGHQV PDDETIFKFK HAVNGFLKEN KDNDKLIGV
Highest antigen sequence identity to the following orthologs:
- Mouse: 78%
- Rat: 78%
Target Information
DUSP11 (dual specificity phosphatase 11, RNA/RNP complex 1-interacting) is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate target kinases by dephosphorylating phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different family members exhibit distinct substrate specificities, tissue distributions, subcellular localizations, and inducibility modes.
DUSP11 is localized to the nucleus and binds directly to RNA and splicing factors, suggesting involvement in nuclear mRNA metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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