Thermo Fisher Scientific ATG2B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive test controls include: HepG2, MCF7, A-549, SW480, Mouse kidney, Rat liver.
The target is usually found in the following locations: Lipid droplet, Peripheral membrane protein, Preautophagosomal structure membrane.

Immunogen sequence:
IQYIASYGDL QTPNKADMKP GAFQRRSKVD SSGRSSSRGP VLPEADQQML RDLMSDAMEE IDMQQGTSSV KPQANGVLDE KSQIQEPCCS DLFLFPDESG NVSQESGPTY ASFSHHFISD AMTGVPTEND DFCILFAPKA AMQEKEEEPV IKIMVDDAIV IRDNYFSLPV NKTDTSKAPL HFPIPVIRYV VKEVSLVWHL YGGKDFGTVP PTSPAKSYIS PHSSPSHTPT RHGRNTVCGG K

Target Information

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.