Thermo Fisher Scientific GTF2H2 Polyclonal Antibody
Rabbit polyclonal antibody against human GTF2H2, validated for WB and ICC/IF. Detects endogenous TF2H2 with high specificity. Suitable for human, mouse, and rat samples. Supplied as liquid, 1 mg/mL, stored at -20°C.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GTF2H2 (Accession Q13888), corresponding to amino acid residues M1–E48 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850606 |
Product Specific Information
Antibody detects endogenous levels of total TF2H2.
Target Information
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II and basal transcription factors. The binding of TFIID (TBP) to the TATA box initiates the formation of a multiprotein complex including TFIIA, TFIIB, TFIIE, TFIIF, and TFIIH (BTF2).
TFIIH is a multisubunit transcription/DNA repair factor with several enzymatic activities. Its core includes subunits p89 (XPB/ERCC3), p62, p52, p44, and p34. Additional subunits include p80 (XPD/ERCC2) and a ternary kinase complex (Cdk7, cyclin H, MAT1). Both p89 and p80 have ATP-dependent helicase activity, while p62, p52, and p44 are involved in nucleotide excision repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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