Thermo Fisher Scientific SETD1B Polyclonal Antibody
Thermo Fisher Scientific의 SETD1B Polyclonal Antibody는 마우스 단백질 Setd1b를 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 ELISA에 적합하며, KLH-결합 합성 펩타이드로 면역화되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| ELISA | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptides containing sequences from the central part of the protein corresponding to mouse Setd1b (Set domain containing 1B). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| RRID | AB_2606898 |
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA.
VISA is a mitochondrial membrane protein identified as a critical component in the IFN-β signaling pathway, recruiting IRF-3 to RIG-I and activating NF-kappa-B. It also interacts with other innate immune pathway components such as TRIF, TRAF2, and TRAF6, as well as kinases IKK-α, IKK-β, and IKK-ι through its C-terminal region.
Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. At least three isoforms of VISA are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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