Thermo Fisher Scientific RASSF1 Monoclonal Antibody (OTI3C2), TrueMAB
RASSF1 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI3C2). Western blot과 Immunocytochemistry에 적합. Affinity chromatography로 정제된 액상 항체로, PBS/BSA/glycerol buffer에 보관. 암 관련 연구 및 세포 주기 조절 연구에 활용 가능.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C2 |
| Immunogen | Full length human recombinant protein of human RASSF1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The RASSF1 gene encodes a protein similar to RAS effector proteins. Loss or altered expression of this gene is associated with the pathogenesis of various cancers, suggesting its tumor suppressor function. Inactivation of this gene correlates with hypermethylation of its CpG-island promoter region. The encoded protein interacts with DNA repair protein XPA and inhibits cyclin D1 accumulation, inducing cell cycle arrest. Seven alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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