Thermo Fisher Scientific CDK7 Polyclonal Antibody
CDK7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin) 분석에 적합합니다. 고순도의 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 기반의 안정한 액상 형태로 제공됩니다. 인간 시료에 반응합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDK7. Recombinant protein control fragment (Product # RP-102518) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789480 |
Product Specific Information
Immunogen sequence:
GCILAELLLR VPFLPGDSDL DQLTRIFETL GTPTEEQWPD MCSLPDYVTF KSFPGIPLHH IFSAAGDDLL DLIQGLFLFN PCARITATQA LKMKYFSNRP GPTPGCQLPR PNCPVETLKE QSNPALAIKR KRTEALEQGG LPKKLI
Target Information
The trimeric complex of CDK7, cyclin H, and MNAT1 functions as a Cdk-activating kinase (CAK). It is an essential component of transcription factor TFIIH, involved in transcription initiation and DNA repair. This complex provides a direct link between transcription regulation and the cell cycle. The bound complex is important in the normal double-strand break repair function of BRCA1. CDK7 may be a target of germline cancer-inducing mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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