Thermo Fisher Scientific GP130 Recombinant Rabbit Monoclonal Antibody (001)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal-origin-free formulation
• Broader immunoreactivity due to the diverse rabbit immune repertoire

This antibody specifically recognizes Mouse IL6ST/gp130/CD130.

Target Information

The IL6ST (gp130/CD130) protein acts as a signal transducer shared by multiple cytokines such as IL6, CNTF, LIF, and OSM. It functions as part of the cytokine receptor complex, and its activation depends on cytokine-receptor binding.
vIL6, encoded by Kaposi sarcoma-associated herpesvirus, can directly activate this protein without IL6R. Mouse knockout studies indicate its critical role in regulating myocyte apoptosis.
Alternative splicing generates distinct isoforms of this protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.