Thermo Fisher Scientific VPS34 Polyclonal Antibody
Rabbit polyclonal antibody against human VPS34 (PIK3C3). Validated for Western blot. Recognizes multiple species including mouse, rat, and zebrafish. Suitable for studying autophagy, mTOR signaling, and intracellular trafficking. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 492–887 of Human PI 3 Kinase Class 3 (VPS34) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.02 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546160 |
Product Specific Information
- Recommended positive controls: A431, 293T
- Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (91%), Xenopus laevis (95%), Dog (100%), Pig (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PIK3C3 (hVPS34) is the sole class III member of the PI3 Kinase family. It phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PI(3)P], which recruits downstream effectors containing FYVE and Phox domains to membranes.
PIK3C3 is involved in coupling nutrient signaling to mTOR and plays a role in autophagy and intracellular trafficking. It regulates degradative endocytic trafficking, is required for the abscission step in cytokinesis (likely via PI3KC3-C2), and is essential for lysosomal enzyme precursor transport from early to late endosomes.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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