Thermo Fisher Scientific TAB1 Polyclonal Antibody
TAB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 210–504 of Human TAB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546159 |
Product Specific Information
- Recommended positive controls: A431, Molt-4, Neuro 2A, C8D30, NIH-3T3, Raw264.7, PC-12, Rat2
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (81%), Pig (97%), Chicken (91%), Rhesus Monkey (100%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1)는 MAP kinase kinase kinase MAP3K7/TAK1의 조절 인자로, TGF beta, interleukin 1, WNT-1 등 다양한 세포 내 신호 전달 경로를 매개합니다. TAB1은 TAK1 kinase를 활성화하며, C-terminal 영역은 TAK1 결합 및 활성화에 충분하고, N-terminal 일부는 TGF beta의 음성 조절 인자로 작용합니다. 또한 MAPK14/p38alpha와 상호작용하여 MAPK14의 생물학적 반응에 대한 대체 활성화 경로를 제공합니다.
⚠ WARNING
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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