Thermo Fisher Scientific Plasminogen Monoclonal Antibody (10A1)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,500
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Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent
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ELISA

• Tested Dilution: Assay-dependent
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Product Specifications

Product Specific Information

A suggested positive control for this product is human plasma.

Target Information

Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70–200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase, and streptokinase to form plasmin. Activation results from cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain containing 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis, and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis, and pulmonary embolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.