Thermo Fisher Scientific Human IRAK1, GST Tag Recombinant Protein
인간 IRAK1 단백질을 GST 태그 형태로 발현한 재조합 단백질. Toll/IL-1 신호 경로 연구용으로 적합하며, 정제된 액상 형태로 제공. -80°C에서 안정적으로 보관 가능하며, 키나아제 활성 분석에 사용됨.
- 카탈로그번호
- PV4439
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human IRAK1, GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | 194–712 |
| Tag | GST-tag |
| Molecular Weight | 83.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris, pH 7.5, with 0.02% Triton X-100, 50% glycerol, 150 mM NaCl, 0.5 mM EDTA, 2 mM DTT |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
- For larger sizes, aliquot preparation may reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
- Never store kinase diluted.
- Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
- Protein Form: Recombinant, Catalytic
Target Information
IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases involved in Toll/IL-1 signaling pathways. Upon TLR activation, IRAK1 is recruited by MYD88 to the receptor-signaling complex, where it is phosphorylated by IRAK4 and undergoes autophosphorylation, leading to kinase activation.
IRAK1 can also phosphorylate TIRAP, promoting its ubiquitination and degradation, and phosphorylates IRF7 to induce its activation and nuclear translocation. This process triggers transcriptional activation of type I interferon genes, promoting an antiviral cellular state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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