Thermo Fisher Scientific LAMTOR4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LAMTOR4, validated for Western blot. Recognizes Ragulator complex component involved in mTORC1 activation. Supplied as liquid, unconjugated, purified by antigen affinity chromatography, suitable for HeLa and S...
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human LAMTOR4/C7orf59 recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.74 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736080 |
Product Specific Information
- Positive Control: HeLa, SKNSH
- Predicted Reactivity: Mouse (95%), Rat (96%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
LAMTOR4 is part of the Ragulator complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. LAMTOR4 is activated by amino acids through a mechanism involving the lysosomal V-ATPase. Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases act as a scaffold recruiting mTORC1 to lysosomes, where it is subsequently activated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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