Thermo Fisher Scientific TDP1 Monoclonal Antibody (OTI4H1), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The TDP1 protein is involved in repairing stalled topoisomerase I-DNA complexes by hydrolyzing the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3′ phosphate of DNA. It may also remove glycolate from single-stranded DNA containing 3′ phosphoglycolate, suggesting a role in repairing free-radical-mediated DNA double-strand breaks.
This gene belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations are associated with spinocerebellar ataxia with axonal neuropathy (SCAN1). Two major transcript variants encoding the same isoform have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.