Thermo Fisher Scientific Cyclin A Polyclonal Antibody
Cyclin A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포주기 연구 및 Cyclin 관련 단백질 분석에 유용합니다.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from C-terminus of human Cyclin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Nuclear
Target Information
Cyclins are key regulatory proteins involved in the control of the eukaryotic cell cycle. The mitotic cyclin B/Cdc2 p34 kinase complex is a well-characterized example, acting as a component of the maturation-promoting factor. Cyclin A accumulates earlier than cyclin B during the cell cycle, is involved in S phase regulation, and associates with cyclin-dependent kinase-2 (Cdk2). Cyclin A also plays a role in cell transformation and forms complexes with E1A, transcription factors DRTF1 and E2F, and retinoblastoma protein p110.
A second form, Cyclin A1, shares high sequence homology with Xenopus cyclin A1 and is primarily expressed in germ cells. Cyclin A1 can associate with Cdk2, p39, and Cdc2 p34.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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