Thermo Fisher Scientific RON Polyclonal Antibody
Human RON 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 검증 완료. KLH 결합 합성 펩타이드로 면역화되어 높은 특이성과 재현성을 제공. 연구용으로 세포 증식 및 이동 관련 RON 단백질 분석에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptides between amino acids 22–51 and 1370–1400 from the N-terminal and C-terminal regions of human RON |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2266858 |
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer resulting from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain.
In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and is implicated in the progression of several epithelial cancers. MST1R/RON expression has been documented in many normal human tissues, including colon, mouth, prostate, and testis, as well as in cancerous tissues such as colon, prostate, stomach, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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