Thermo Fisher Scientific GSDMD Polyclonal Antibody
GSDMD 단백질의 전구체 및 절단된 N-말단 조각을 모두 검출하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 적합하며 Human, Mouse, Rat 반응성. 액상 형태로 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: View 2 publications
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1:50–1:200
- Publications: View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GSDMD (Accession P57764), corresponding to amino acid residues W50–G100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899966 |
Product Specific Information
Antibody detects endogenous levels of total GSDMD protein, including precursor and the cleaved N-terminal fragment.
Target Information
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is cleaved by inflammatory caspases CASP1 or CASP4 during canonical and non-canonical inflammasome activation. After cleavage, GSDMD translocates to the plasma membrane and binds strongly to inner leaflet lipids such as phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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