Thermo Fisher Scientific PTPN22 Polyclonal Antibody
PTPN22 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제, PBS/glycerol 버퍼에 보관. 자가면역 질환 연구용으로 적합.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human PTPN22 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635603 |
Product Specific Information
This antibody detects endogenous levels of total PTPN22 protein.
Target Information
The protein tyrosine phosphatase PTPN22 (also known as PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with increased risk of several autoimmune diseases including type 1 diabetes and rheumatoid arthritis.
A missense SNP in PTPN22 encodes a hematopoietic-specific phosphatase known as Lyp, with the risk allele found in approximately 17% of the general Caucasian population and 28% of those with rheumatoid arthritis.
This variant may disrupt the P1 proline-rich motif critical for interaction with the SH3 domain of CSK (cytoplasmic tyrosine kinase), potentially altering T-cell activation regulation.
The specific interaction between CSK and PTPN22 suggests that PTPN22 may function as an effector and/or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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