Thermo Fisher Scientific SMURF1 Polyclonal Antibody
인간 SMURF1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 용액에 보존. 세포 극성과 이동성 조절 연구에 적합.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SMURF1 (Product # RP-106612) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856821 |
Product Specific Information
Immunogen sequence:
DSTGAAAGGG NCRFVESPSQ DQRLQAQRLR NPDVRGSLQT PQNRPHGHQS
Target Information
Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which activate the SMAD signaling pathway.
Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas activin and TGFB receptors (e.g., ACVR1 and TGFBR1) target SMAD2 and SMAD3.
Phosphorylation of these receptor-regulated SMADs induces association with SMAD4.
Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity, maintaining tumor cell morphology and motility. PKCζ, an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions to control local RhoA levels. Smurf1 links the polarity complex to RhoA degradation in lamellipodia and filopodia, preventing RhoA signaling during dynamic membrane movements.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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