Thermo Fisher Scientific SCAMP2 Monoclonal Antibody (OTI1H10)

Applications and Tested Dilution

Product Specifications

Target Information

Secretory carrier membrane proteins (SCAMPs) are components of post-Golgi membranes involved in membrane trafficking. In fibroblasts, SCAMPs are concentrated in compartments related to recycling of cell surface receptors and endocytosis. In neurons, they are associated with synaptic vesicles, secretion granules, and transporter vesicles.

SCAMPs consist of four central transmembrane regions and a cytoplasmic tail. Of the five known SCAMPs, SCAMPs 1–3 contain cytoplasmic N-terminal regions with NPF repeats that interact with EH domain proteins involved in vesicle budding from the plasma membrane or Golgi complex. SCAMPs 4 and 5 lack N-terminal NPF repeats. SCAMPs 1–4 are ubiquitously coexpressed, while SCAMP 5 is brain-specific and expressed late in development, coinciding with the expansion of mature synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.