Thermo Fisher Scientific ABH1 Recombinant Rabbit Monoclonal Antibody (JE56-09)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

Product Specifications

Species Reactivity

Human, Zebrafish

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE56-09

Immunogen

Synthetic peptide within C-terminal Human ALKBH1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ABH1,uniProtId:Q13686-1,ncbiNodeId:9606,antigenRange:389,antigenLength:389,antigenImageFileName:MA5-42511_ABH1_Q13686-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42511_ABH1_Q13686-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2911652

Product Specific Information

Positive Control: Human placenta tissue lysate, MCF-7 cell lysate, Daudi cell lysate, A549 cell lysate, zebrafish tissue lysates, human liver carcinoma tissue, human skin tissue, human small intestine tissue.

Subcellular Location: Mitochondrion, Nucleus.

Target Information

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.