Thermo Fisher Scientific BMP-10 Polyclonal Antibody
인간 BMP-10 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. Affinity chromatography로 정제되었으며, PBS와 50% glycerol buffer에 보관. 심장 발달 관련 BMP-10 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BMP10 (Accession O95393), corresponding to amino acid residues L239–S289 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854288 |
Product Specific Information
Antibody detects endogenous levels of total BMP10.
Target Information
Bone morphogenetic proteins (BMPs) are a subfamily within the TGF-beta superfamily of signaling proteins. They are widely distributed and play roles in various physiological processes both pre- and postnatally.
BMP-10 is crucial in embryonic heart development by stimulating and maintaining cardiomyocyte proliferation. It signals through receptor complexes such as BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6, leading to phosphorylation of SMAD transcription factors (SMAD1, SMAD5, SMAD8) or SMAD-independent pathways.
BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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