Thermo Fisher Scientific CYP11B1/CYP11B2 Polyclonal Antibody
CYP11B1/CYP11B2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, 액상 형태로 제공. 인체 Cytochrome P450 11B1/2의 C-말단 합성 펩타이드로 면역화됨. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CYP11B1/CYP11B2 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of human Cytochrome P450 11B1/2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556136 |
Target Information
The steroid 11β-hydroxylase gene (Cyp11b-1) is a marker for functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence.
Human aldosterone synthase (CYP11B2) is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region.
The inherited disorder glucocorticoid-remediable aldosteronism results from a chimeric gene duplication between CYP11B1 and CYP11B2, characterized by hyperaldosteronism and elevated levels of 18-hydroxycortisol and 18-oxocortisol under ACTH control.
Notes
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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