Thermo Fisher Scientific CD138 Recombinant Rabbit Monoclonal Antibody (001)

Applications

Tested Application

• ELISA (ELISA): 1:5,000–1:10,000 dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody shows specificity for Human Syndecan-1/CD138/SDC1.

Target Information

CD138 (Syndecan-1) is a transmembrane proteoglycan that binds various cytokines and modulates their activity, as well as extracellular matrix components. It influences multiple developmental processes.

• Expressed mainly in differentiating keratinocytes
• Upregulated in the epidermis upon tissue injury
• Highly expressed on plasma cells; also detected on fibroblasts, vascular smooth muscle cells, and endothelial cells
• Expression changes correlate with cancerous transformation
• Soluble sCD138 serum levels serve as a prognostic factor in cancerogenesis

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.