Thermo Fisher Scientific CXCR3 Monoclonal Antibody (5C10E6)
CXCR3 단클론 항체(5C10E6)는 인간 시료에 반응하며, Western blot, IHC, Flow cytometry, ELISA에 적합합니다. 고순도 Protein G 정제, 1 mg/mL 농도의 액상 형태로 제공되며, 염증 반응 관련 연구에 유용한 연구용 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5C10E6 |
| Immunogen | Purified recombinant fragment of human CD183 (AA: extra mix) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091263 |
Target Information
The CXCR3 gene encodes a G protein-coupled receptor that binds chemokines IP10 (interferon-γ-inducible 10 kDa protein), Mig (monokine induced by interferon-γ), and I-TAC (interferon-inducible T-cell alpha chemoattractant). These chemokines belong to the CXC subfamily, characterized by a single amino acid separating the first two conserved cysteine residues.
Binding of chemokines to CXCR3 triggers cellular responses involved in leukocyte trafficking, including integrin activation, cytoskeletal rearrangement, and chemotactic migration. Pertussis toxin inhibition suggests coupling with Gi-type heterotrimeric G proteins. Signaling may involve cascades similar to other chemokine receptors.
Chemokine-induced desensitization leads to transient signaling due to receptor internalization, with responsiveness restored after receptor dephosphorylation and recycling. CXCR3 is highly expressed in effector/memory T cells and T cells within inflamed tissues. The receptor and its ligands play key roles in recruiting inflammatory cells, making CXCR3 a potential target for small-molecule antagonists in inflammatory disease treatment. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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