Thermo Fisher Scientific TNFAIP3 Recombinant Rabbit Monoclonal Antibody (ARC0355)
TNFAIP3 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체 ARC0355. Western blot, IHC, ELISA 등 다양한 응용에 사용 가능. 높은 특이성과 재현성을 제공하며, 인간 시료 반응성. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0355 |
| Immunogen | Synthetic peptide within amino acids 450–550 of human TNFAIP3 (UniProt ID: P21580) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849179 |
Product Specific Information
Immunogen sequence:
PEESTGGPHS APPTAPSPFL FSETTAMKCR SPGCPFTLNV QHNGFCERCH NARQLHASHA PDHTRHLDPG KCQACLQDVT RTFNGICSTC FKRTTAEASS S
Target Information
TNFAIP3 (also known as A20) is located in chromosome band 6q23, a region often deleted in B cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and several non-Hodgkin lymphoma subtypes. TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 also suppresses TLR2- and TLR4-mediated IL-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses. At least two isoforms of TNFAIP3 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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