Thermo Fisher Scientific CD63 (Late Endosomes Marker) Monoclonal Antibody (SPM524)

Thermo Fisher Scientific CD63 (Late Endosomes Marker) Monoclonal Antibody (SPM524)

Applications and Tested Dilution

Product Specifications

Additional Formats

• PE conjugated format available
• Custom conjugation requests accepted

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family found in late endosomes, lysosomes, and secretory vesicles. It is also present on the plasma membrane following cell activation and serves as a basophil activation marker. In mast cells, CD63 expression does not require activation. CD63 interacts with integrins, influences phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. It also functions as a T-cell costimulation molecule and can serve as a prognostic marker in early-stage carcinomas. CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunctions in CD63 are associated with melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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