Thermo Fisher Scientific CD63 (Late Endosomes Marker) Monoclonal Antibody (SPM524)
CD63 단백질을 표적하는 SPM524 클론의 단일클론 항체로, 인간 및 마우스 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, Protein A/G 정제 및 PBS 버퍼에 보존됩니다. Late endosome 및 lysosome 마커로 연구용으로 사용됩니다.
- 카탈로그번호
- 967-MSM1X-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD63 (Late Endosomes Marker) Monoclonal Antibody (SPM524)
Thermo Fisher Scientific CD63 (Late Endosomes Marker) Monoclonal Antibody (SPM524)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM524 |
| Immunogen | Smooth plasma membrane fraction of MeWo cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
- PE conjugated format available
- Custom conjugation requests accepted
Target Information
CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family found in late endosomes, lysosomes, and secretory vesicles. It is also present on the plasma membrane following cell activation and serves as a basophil activation marker. In mast cells, CD63 expression does not require activation. CD63 interacts with integrins, influences phagocytosis and cell migration, and is involved in H/K-ATPase trafficking and ROMK1 channel regulation. It also functions as a T-cell costimulation molecule and can serve as a prognostic marker in early-stage carcinomas. CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells. It is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunctions in CD63 are associated with melanoma and Hermansky-Pudlak Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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