Thermo Fisher Scientific APBA1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total APBA1.

Target Information

The munc-18 interacting protein (Mint) family is a group of evolutionarily conserved adaptor proteins involved in membrane transport and organization. Mammals have three Mint isoforms: Mint1, Mint2, and Mint3.

• Mint1 and Mint2 are expressed primarily in the brain and bind to Munc18, a key component of the synaptic vesicle fusion machinery.
• Mint3 is ubiquitously expressed at low levels in the brain and testis and does not interact with Munc18.
• Mint3 interacts with the Alzheimer’s disease-related amyloid precursor protein (APP) through its PTB and PDZ domains, linking APP to transport machinery components and regulating its transport, endocytosis, and metabolism.
  Abnormal APP metabolism is associated with early-onset Alzheimer’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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