Thermo Fisher Scientific AP2M1 Polyclonal Antibody
AP2M1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(PFA) 실험에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도 Affinity chromatography로 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AP2M1 (Accession Q96CW1), corresponding to amino acid residues I133–L183 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899490 |
Product Specific Information
This antibody detects endogenous levels of total AP2M1.
Target Information
The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family.
The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, responsible for proton pumping in the acidification of endosomes and lysosomes.
AP2M1 associates with the HIV-1 protein Nef, suggesting Nef may use the AP-2 complex to enhance endocytosis of CD4 and class I MHC.
It also plays a role in regulating intracellular trafficking and function of CTLA-4 protein.
At least two isoforms of AP2M1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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