Thermo Fisher Scientific HSF2 Monoclonal Antibody (OTI2A7)
HSF2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 시료에 반응하며, 고순도 액상 형태로 제공되어 안정적인 신호 검출이 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 74–324 of HSF2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724485 |
Target Information
Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing heat shock genes. In eukaryotes, this expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF1 and HSF2) play key roles in this regulation.
HSF1 and HSF2 are upregulated by estrogen at both mRNA and protein levels. HSF1 is normally a monomer with repressed transcriptional activity due to phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity, and translocates to the nucleus.
HSF2 activity is associated with differentiation and development and binds DNA as a trimer similar to HSF1. Both are induced by proteasome inhibitors of the ubiquitin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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