Thermo Fisher Scientific Phospho-Zap-70 (Tyr315, Tyr319) Polyclonal Antibody
인간 ZAP-70의 Tyr315 및 Tyr319 인산화 부위를 인식하는 폴리클로날 항체입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. T세포 신호전달 연구용으로 사용되며, -20°C에서 보관합니다.
- 카탈로그번호
- 44232G
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human ZAP-70 that contains tyrosines 315 and 319. The sequence is conserved in mouse. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533610 |
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase that belongs to the Syk family. It is expressed exclusively in T-cells and natural killer cells and is essential for T-cell receptor activation. Upon TCR engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region between the SH2 and kinase domains. Phosphorylation at Tyr315 (Vav binding site) and Tyr319 (Lck binding site) enhances ZAP70-mediated lymphocyte signaling, while Tyr292 phosphorylation attenuates activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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