Thermo Fisher Scientific Phospho-beta Catenin (Ser45) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton.

Studies show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways including tyrosine kinases, phosphatases, and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes, and signaling pathways may regulate morphogenesis.

Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Pathological roles have been identified in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and tumor development. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that stimulate transcription of target genes such as cyclin D and c-myc, promoting cell proliferation. This mechanism underlies its role in tumorigenesis of solid tumors including breast, colon, liver, lung, gastric, prostate, and skin.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.