Thermo Fisher Scientific TRPC6 Polyclonal Antibody
TRPC6 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. Mouse와 Rat 반응성. 합성 펩타이드 항원으로 제작되었으며, Lyophilized 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:4,000 | - |
| Immunohistochemistry (IHC) | 1:4,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from rat TRPC6 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPC6.
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium.
Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily, divided into three major families including the “canonical TRP” (TRPC) family. The seven members of this family share activation through PLC-coupled receptors and are components of receptor-regulated cation channels in different cell types.
Members of the TRPC3/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel, activated by DAG in a PKC-independent manner and insensitive to IP3 activation.
There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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