Thermo Fisher Scientific AIFM1 Monoclonal Antibody (OTI5D2), TrueMAB
AIFM1 단백질을 인식하는 Mouse monoclonal antibody (clone OTI5D2). Western blot과 IHC(P)에서 검증됨. Human 및 Mouse 시료에 반응. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 134–483 of human AIFM1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis Inducing Factor (AIF) is a mitochondrial protein that plays a critical role in apoptosis by inducing chromatin condensation and DNA fragmentation. Upon apoptotic stimuli, AIF translocates from mitochondria to the nucleus, promoting release of apoptogenic proteins such as cytochrome c and caspase-9. AIF is highly conserved between human and mouse and is widely expressed. Mutations in the AIF gene are associated with combined oxidative phosphorylation deficiency 6, leading to severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants, and a related pseudogene exists on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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