Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 is a calcium-selective cation channel involved in Ca(2+) uptake in various tissues, including intestinal calcium reabsorption. The channel is activated by low internal calcium levels, possibly including intracellular calcium store depletion, and exhibits inward rectification.
Inactivation involves both rapid Ca(2+)-dependent and slower Ca(2+)-calmodulin-dependent mechanisms, possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg(2+) in a voltage-independent manner.
Heteromeric assembly with TRPV5 modifies channel properties, and TRPV5–TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin, with S100A10 interaction required for plasma membrane trafficking.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.