Thermo Fisher Scientific RNAse H2A Polyclonal Antibody
Thermo Fisher Scientific의 RNASEH2A 폴리클로날 항체로, Western blot 및 IHC(P) 검증 완료. 인간 시료 반응성, Rabbit IgG 유래 비결합 항체. 단백질 A 정제, PBS+2% sucrose 보존. RNA/DNA hybrid 분해 효소 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.25 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human RNASEH2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610015 |
Product Specific Information
Peptide sequence:
AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE
Sequence homology:
Cow: 100%; Dog: 93%; Goat: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 93%; Yeast: 90%; Zebrafish: 100%
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their main function is to remove the RNA strand from RNA/DNA hybrids formed during DNA replication and repair. RNAse H2 consists of three subunits, all required for enzymatic activity.
Mutations in RNAse H2A or its subunits are linked to Aicardi-Goutières syndrome (AGS), a neurological disorder resembling viral brain infections, characterized by elevated IFN-alpha in cerebrospinal fluid. Similar pathologies occur with TREX1 mutations, indicating that RNAse H2 and TREX1 may share roles in preventing accumulation of intracellular nucleic acids and inflammation via innate immune activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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