Thermo Fisher Scientific RNAse H2A Polyclonal Antibody
Thermo Fisher Scientific의 RNAse H2A Polyclonal Antibody는 인간 RNASEH2A의 C-말단을 인식하는 토끼 유래 IgG 항체입니다. Western blot과 IHC에 최적화되어 있으며, 액상 형태로 제공됩니다. DNA 복제 및 수리 연구용으로 적합합니다.
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- PA541815
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human RNASEH2A (aa 246–295) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2610014 |
Product Specific Information
- Peptide sequence: EKEAEDVIWE DSASENQEGL RKITSYFLNE GSQARPRSSH RYFLERGLES
- Sequence homology: Human: 100%
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their major role is to remove the RNA strand from hybrids formed during DNA replication and repair. RNAse H2 is composed of three subunits, all required for enzymatic activity. Mutations in RNAse H2A or other subunits cause Aicardi-Goutieres syndrome (AGS), a neurological disorder with symptoms similar to viral brain infections, including elevated IFN-alpha levels in cerebrospinal fluid. Similar phenotypes are observed with mutations in TREX1, suggesting a shared role in preventing accumulation of intracellular nucleic acids and activation of innate immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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