Thermo Fisher Scientific HRAS Monoclonal Antibody (OTI1H3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:4000

Product Specifications

Target Information

Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Mammalian cells contain three Ras proto-oncogenes coding for closely related Ras proteins: H-, K-, and N-Ras. Oncogenic mutations in Ras genes are present in approximately 30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibits apoptosis. K-Ras mutations are common in pancreatic, colorectal, and nonsmall-cell lung carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies, and hepatocellular carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.