Thermo Fisher Scientific Bestrophin 1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant condition characterized by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive loss of central vision.
This material appears as a yellow mass resembling an egg yolk that darkens and becomes irregular in color over time (“scrambling the egg”).
Best disease often results from mutations in the Bestrophin gene, which encodes a protein with four transmembrane domains localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium, and missense mutations can reduce or abolish membrane current mediated by Bestrophin.
The human Bestrophin gene encodes a 585 amino acid protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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